Eukaryotic gene expression is a tightly regulated process. While some genes are constitutive, many are turned on only in certain conditions defined by environmental cues within or outside the cell. This regulation ensures the timing and controls the rate at which gene products are produced when and where they are needed in the cell.

Gene regulation occurs at various levels. In this course, we will examine the various molecular mechanisms that regulate gene expression at the transcription and post-transcription levels. We will then look at select signaling pathways and consider how environmental cues and the intracellular signal transduction mechanism influence the expression or repression of certain genes. Finally, we will discuss cancer and host immunity in the context of deregulated and/or misregulated gene expression pathways in cells.